Methyl B12 and methyl Folate in one chewable tablet, ZARY. It is formulated by a UCLA-trained medical doctor, Dr. Sarfraz Zaidi, MD, FACE, FACP, who tested it in his medical practice before making it available to the public.
Active Ingredients in ZARY:
Each chewable tablet of ZARY contains:
Folate as [6S]-5-methyltetrahydrofolic acid) = 800 mcg
Vitamin B12 = 1000 mcg (as methylcobalamin)
One chewable tablet per day or as recommended by a healthcare professional.
ZARY : A Perfect Combination Of Vitamin B12 and Folate
ZARY is a perfect combination of vitamin B12 and folate.* This is why:
Methyl B12 is the active form of vitamin B12. Similarly, methyl Folate is the active form of folate. However, many people cannot convert vitamin B12 and Folate in their diet to the active forms: methyl B12 and methyl folate. That’s why ZARY has methyl B12 and methyl Folate instead of regular vitamin B12 and folate.
Methyl B12 and Methyl Folate are important for the normal health of our DNA. In this way, these two vitamins play an important role in the health of each and every cell in our body.*
Why Take B12 And Folate Together?
Both B12 and folate are important for the proper synthesis of red blood cells in the bone marrow.
Deficiency of either B12 or folate can lead to a defect in the synthesis of the red blood cells. Consequently, you have red blood cells which are too large and have difficulty leaving the bone marrow. As a result, there is a smaller number of red blood cells circulating in the blood.
The net result is macrocytic anemia, which means the size of the red blood cell is bigger than the normal range.
B12 deficiency May Be Masked With Folate-Alone Supplementation
If a person has macrocytic anemia due to vitamin B12 deficiency, and you mistakenly treat it with folate supplementation alone, the anemia will resolve. However, the effects of B12 deficiency on the nervous tissues will continue. Consequently, that person may end up with an advanced neurologic disorder.
Should I take B12 Supplement?
- Consider taking Vitamin B12 supplement if you are an elderly person because aging can interfere with B12 absorption. Similarly, people who consume alcohol excessively may not absorb vitamin B12 and should benefit from a B12 supplement.
- Vegans and vegetarians are at risk of vitamin B12 deficiency because B12 primarily comes from animal products – beef, lamb, ham, chicken, turkey, fish, eggs, milk, cheeses, and yogurt. If you avoid these B12-rich foods, you are likely to develop B12 deficiency.
- Certain common medications are known to increase your risk of B12 deficiency. These drugs include heartburn medications such as omeprazole (Prilosec), esomeprazole (Nexium), lansoprazole (Prevacid), cimetidine (Tagamet), ranitidine (Zantac), famotidine (Pepcid AC.) In addition, metformin (Glucophage) – an antidiabetic drug – frequently causes B12 deficiency.
- Broad-spectrum antibiotics kill the healthy bacteria in our intestines which can lead to B12 deficiency, especially if antibiotics are used for a prolonged period.
- Some gastrointestinal disorders can result in B12 deficiency. These disorders include chronic pancreatitis, atrophic gastritis, autoimmune gastritis, small intestinal resection or stomach surgery, gluten sensitivity, Crohn’s disease.
Are B12 supplements safe?
Vitamin B12 supplements are generally safe, even in large quantities. Vitamin B12 is a water-soluble vitamin. Whatever the body does not need gets excreted in the urine. That’s why you need to take B12 daily either in food or as a supplement.
Dose of Vitamin B12 Supplement
The usual dose of vitamin B12 in supplements is 1000 mcg per tablet.
Who needs Folate Supplement?
You may need folate supplement if:
- You are about to get pregnant, or you are already pregnant.
- You consume alcohol excessively.
- You do not eat green leafy vegetables regularly.
- You take medicines that can cause folate deficiency. These are: metformin, anti-seizure drugs (such as phenytoin and carbamazapine), methotrexate, sulfasalazine, triamterene, heartburn medicines (such as omeprazole, cimetidine, ranitidine), and tetracycline antibiotic.
- You have a malabsorption syndrome such as Crohn’s disease, Celiac disease, chronic enteritis and other malabsorption syndromes.
- You have a genetic defect that decreases the conversion of dietary folate into Active folate (5-MTHF). You can choose to have genetic testing for the MTHFR gene. However, if you have an elevated homocysteine level, you can presume that you have MTHFR defect. In either case, you need Active folate (5-MTHF) as well as Vitamin B12 and Vitamin B6. You can monitor your homocysteine level to make sure that it comes down with the treatment.
Elevated Homocysteine level may increase your risk of cardiovascular disease, stroke, dementia, Parkinson’s disease and insulin resistance.1
Studies show that Methyl B12 plus Methyl Folate and Vitamin B6 can lower homocysteine level and may reduce the risk of these disorders. That’s why a German, Austrian and Swiss homocysteine society recommends use of vitamin B12 and Folate supplementation for the general public. 2
Are Folate supplements safe?
Folate supplements are generally safe.
How much Folate supplement to take?
The usual dose of folate in supplements is 400 – 800 mcg per tablet.
*These statements have not been evaluated by the Food and Drug Administration.