Vitamins D3 and K2 are important for our optimal health especially the health of the bone, joints, and cardiovascular system (1). Unfortunately, many people are low in these essential vitamins – thanks to our modern lifestyle. Vitamin D deficiency has reached pandemic proportions as most people stay out of sun – the main natural source of vitamin D – due to a variety of reasons. Vitamin D exists in two forms: D3 and D2. Vitamin D3 is the one that our body produces when we are out in the sun. Vitamin D2, on the other hand is what plants produce.
Vitamin K2 exists primarily in two forms: MK4 and MK7. These two forms differ in their duration of activity: MK 4 has a shorter duration while MK7 has a longer duration of activity in our body. Vitamin K2 is mostly present in the following foods: grass-fed butter (MK4), eggs (MK4), yogurt (MK7), fermented cheese (MK7), fermented soy, called natto (MK7), kimchi ( MK7) and Sauerkraut (MK7).
Vitamin K2 is also produced by healthy intestinal bacteria, but in small amounts. Unfortunately, broad-spectrum antibiotics kill your healthy intestinal bacteria.
Why you should take Vitamin D3 and K2 together?
Numerous studies show that vitamin D3 and K2 work together and amplify each other’s action (1). Therefore, it makes perfect sense to use these vitamins together rather than individually.
So, What Is Vitamin D3 and K2 good For?
Scientific studies suggest vitamin D3 and K2 may support:
- healthy bones and joints
- healthy teeth
- healthy immune system
- healthy cardiovascular system
- healthy blood sugar levels
- Healthy mood
How do Vitamin D3 and Vitamin K2 interact?
While vitamin D3 regulates calcium and phosphorus absorption from the intestines, vitamin K2 determines the fate of the calcium: it directs calcium to be deposited in the bones and teeth but prevents its accumulation in the blood vessel wall. In this way, while the bones and teeth get stronger the blood vessel wall may stay free of the calcium deposit. Buildup of calcium deposits in the blood vessel walls is a risk of heart disease (2).
How much Vitamin D3 and K2 you should take?
The NIH (National Institutes of Health) recommends daily dose of Vitamin D as 400-800 IU (10 – 20 mcg) per day for most adults (3). But most vitamin D experts believe this dose is too small to achieve optimal D level for the health benefits of vitamin D beyond the bones. For example, the Endocrine Society recommends at least 1,500 –2,000 IU (37.5 to 50 mcg)/day of vitamin D supplement to raise the blood level of 25(OH)D – test for vitamin D – above 30 ng/ml ( 75 nmol/L.) A level of 25(OH)D below 30 ng/ml is considered low. Endocrine society also recommends using at least 6000–10,000 IU/d) of vitamin D to treat vitamin D deficiency to maintain a 25(OH)D level above 30 ng/ml (4).
There is no established dose of Vitamin K.
Researchers from Maastricht University, The Netherlands used a low dose of Vitamin K2 as Menaquinone -7 (MK7) as 180 microgram per day in postmenopausal women for 3 years . MK7 at this small dose prevented age-related decline in bone mineral density (5).
Vitamin D3 and K2 Side effects
Vitamin D3 and vitamin K2 side effects are rare. Vitamin D toxicity causes your calcium level to go high in your blood. You can develop Vitamin D toxicity if you take very large amounts of Vitamin D for a prolonged period as evidenced by the following two cases.
Researchers from the University of Toronto, Canada, reported 2 cases of high doses of vitamin D (6). The first gentleman had been taking 4,000 I.U./day for 3 years followed by 3 years of 8,000 I.U./day. Serum 25 (OH) vitamin D levels averaged 52 ng/ml, while taking 4,000 I.U./day of vitamin D3. While taking 8,000 I.U./day of vitamin D3, mean serum 25 (OH) vitamin D levels were 104 ng/ml. There was no evidence of vitamin D toxicity. He maintained a normal level of calcium in the blood and urine over the 6 years of the vitamin D3 intake.
The second gentleman was a 39-year-old man diagnosed with multiple sclerosis. He initiated his own dose-escalation schedule. He increased vitamin D3 dose from 8,000 to 88,000 I.U./day over a period of 4 years. At this extremely high dose, his blood 25 (OH) vitamin D level was 450 ng/ml, and his blood calcium was 2.63 mmol/L (reference range (2.2-2.6 mmol/L). As you can see, even at this super-high dose of vitamin D, his serum calcium was only slightly above the upper limit of normal, without any symptoms of toxicity. At this point, he stopped vitamin D3 supplementation. Two months later, his blood calcium values were within reference range; serum 25 (OH) vitamin D concentrations fell by about one-half, to 262 ng/ml. These results help to clarify the human response to higher intakes of vitamin D3.
What Is Special About Dr. Z’s Vitamin D3 with K2
- Clinically tested to be safe and effective: Dr. Z’s Vitamin D3 with K2 was – for years – available to only Dr. Zaidi’s patients in the beginning. These patients were carefully monitored for efficacy as well as any side-effects. Vitamin D level was done at baseline, then periodically at about 3-6 months intervals. Patients were also seen by Dr. Zaidi at these visits. Dr. Z’ Vitamin D3 with K2 was found to be effective in raising vitamin D level into the normal range in 98% of the patients. And no side-effects were reported. Dr. Zaidi also noticed some amazing results from his Vitamin D3 with K2 supplement. He shared these clinical findings in his well-acclaimed book, “Power of Vitamin D” first published in 2010, when most people were not even aware of the benefits of vitamin D.
- Highest quality, natural ingredients
- Manufactured in the USA at a GMP-Certified and FDA-Registered facility from domestic and global natural ingredients
- One small easy to swallow capsule
- Money back guarantee
- Free shipping and handling
Vitamin D3 5000 IU ( 125 mcg) plus Vitamin K2 MK7 100 MCG per capsule.
One capsule daily preferably with a meal as recommended by a healthcare professional.
Vitamins D3 and K2 are important for our optimal health. A deficiency of these vitamins is common – thanks to our modern lifestyle. Therefore, a vitamin D3 and K2 dietary supplement such as Dr. Z’s vitamin D3 with K2 may support healthy immune system, muscle health, bone and teeth health, healthy glucose metabolism, cardiovascular health and mood.*
- Adriana J. van Ballegooijen, 1 Stefan Pilz, 2 , 3 Andreas Tomaschitz, 4 Martin R. Grübler, 2 , 5 and Nicolas Verheyen. The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review. Int J Endocrinol. 2017; 2017: 7454376
- Wei Liu,1 Yue Zhang,2 Cheuk-Man Yu,3 Qing-Wei Ji,1 Meng Cai,1 Ying-Xin Zhao,1 and Yu-Jie Zhou1Current understanding of coronary artery calcification. J Geriatr Cardiol. 2015 Nov
- Knapen MH, Drummen NE, Smit E, Vermeer C, Theuwissen E. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013 Mar 23
- Kimball S, Vieth R. Self-prescribed high-dose vitamin D3: effects on biochemical parameters in two men. Ann Clin Biochem. 2008 Jan;45(Pt 1):106-10.