Glupride multi contains Alpha Lipoic Acid-Chromium Picolinate-Cinnamon in high doses.
Patients with Typ2 diabetes get depleted in many vitamins and minerals due to their excessive losses in the urine. In addition, they also need special vitamins and minerals to deal with the excessive oxidative stress. In this way, patients with type 2 diabetes have special nutritional needs for vitamins and minerals. Glupride Multi is a unique vitamin/herbal formula designed to promote healthy glucose levels naturally already within the normal range.
How is GLUPRIDE Multi different from other Multivitamins?
Most multivitamins contain Potassium. The majority of patients with diabetes are on an Ace-inhibitor drug (such as Altace, Vasotec, Accupril, Zestril, etc.) or an ARB drug (such as Cozaar, Avapro, Atacand, Benicar, Diovan, etc.) These drugs can increase the potassium level in blood, which can be life-threatening. Potassium in a multi-vitamin can further increase this potassium level. Patients usually don’t tell their physicians they’re taking vitamins that contain potassium. When a physician encounters a patient with a high potassium level, they often stop the Ace-inhibitor or ARB drug, inadvertently depriving the patient of the beneficial effects of these helpful drugs. In contrast, all they had to do was to stop the multivitamin that contained potassium and advise the patient on a low potassium diet.
Most multivitamins contain vitamin K1 which may increase the amount of clotting factors in the body. Most diabetics have underlying insulin resistance, which increases the level of many clotting factors, which in turn increases risk for clot formation and acute vascular events, such as a heart attack and stroke. An extra dose of Vitamin K1 in multivitamin preparations may actually be harmful in these patients. It’s like adding fuel to the fire. Also, many of these patients are on Warfarin. Vitamin K1 interferes with Warfarin and it becomes extremely difficult to find the right dose of Warfarin in these patients.
Vitamin K1 is different from Vitamin K2, which actually can prevent from heart disease.
Most multivitamins also contain calcium and iron, both of which can interfere with the absorption of thyroid hormone, which many diabetic patients take.
Compared to many other Multivitamins, Glupride-Multi is designed to be free of Potassium, Vitamin K1, or Iron .
Active Ingredients Of Glupride multi
Glupride Multi contains 21 different vitamins, minerals and herbs. It contains Alpha-Lipoic Acid, Chromium Picolinate, Cinnamon and Coenzyme Q 10 in addition to B vitamins, Vitamin A, Vitamin E, Vitamin C and essential minerals including Selenium, Zinc, Vanadium and Magnesium.
Alpha-lipoic acid is normally produced in cells in small amounts and helps in the normal metabolism of glucose. Alpha-lipoic acid functions as a strong anti-oxidant in the body (1, 2).*
The cells of diabetic patients are under a tremendous amount of daily oxidative stress. That’s why it makes sense to use Alpha-Lipoic acid as a dietary supplement in people with diabetes.*
A number of scientific studies have shown that alpha-lipoic acid promotes normal insulin sensitivity and thus may promote healthy glucose levels already in the normal range (2).*
Several studies have also shown alpha-lipoic acid to be helpful in promoting nerve health in humans (3).*
In Germany, Alpha-lipoic acid has been used for over 30 years. The amount of Alpha-lipoic acid is important! In these studies, the amount used was 600-1800 mg per day. Some multivitamins add a tiny amount of Alpha-lipoic acid, such as 100 mg per day. In contrast, we use a dose of 600 mg per day in Glupride Multi.
Chromium picolinate is required for the normal metabolism of glucose.* Several studies have shown beneficial effects of chromium supplementation in promoting healthy glucose levels.*
One large clinical trial tested chromium picolinate in 833 Type 2 diabetic patients and found a significant improvement in their blood glucose values (4).
The amount of chromium picolinate is also important. Many multivitamins contain only a small amount of chromium picolinate. In contrast, we use a large dose of 600 mcg per day as was used in these clinical studies.*
Physicians have long been intrigued by the beneficial effects of cinnamon on human health.
In December 2003, an excellent scientific study was published in Diabetes Care, (5) in which cinnamon powder was used in 60 patients with Type 2 diabetes. Three daily doses, 1 gram, 3 grams and 6 grams were used. There was a decrease in blood glucose by 18-29%. Serum triglycerides also decreased by 23-30%. Patients consuming 6 grams of cinnamon powder per day appeared to have achieved results earlier (at 20 days), but at 40 days, all doses had the same efficacy in lowering blood glucose and triglycerides level.*
Coenzyme Q10 is a strong antioxidant.* It may help to improve diastolic dysfunction of the heart in patients with hypertension.
Statin drugs such as Lipitor (atorvastatin), Zocor (simvastatin), Pravachol (pravastatin), Mevacor (lovastatin) and Crestor (rosuvastatin) are commonly used in diabetic patients. Unfortunately, these drugs not only reduce cholesterol level, but also may reduce CoQ10 level in the muscles as was demonstrated in a recent study from investigators at Columbia University in the U.S. (6). This phenomenon may explain the muscle aches these patients often experience while on a statin drug. Co Q10 may help to prevent these muscle aches and pains.*
Selenium, Zinc and Magnesium have all been shown to be beneficial to promote healthy glucose levels already in the normal range.*
- Evans JL, Goldfine ID. Alpha-lipoic acid : a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Technol Ther 2000; 2: 401-413.
- Konrad T, Vicini P, Kusterer K et al. Alpha-Lipioc acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care 1999;22:280-287.
- Ziegler D, Reljanovic M, Mehnert H, Gries FA. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol Diabetes 1999;107:421-430.
- Anderson R, Cheng N, bryden N, Polansky M, Cheng N, Chi J, Feng J. Elevated Intakes of supplemental chromium improves glucose and insulin variables in individuals with type 2 diabetes. Diabetes 1997;46:1786-1791.
- Khan A, Safdar M, Khan M, Khan N, Anderson R. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;
- Rundek T, Naini A, Sacco R, Coates K, DiMauro S. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol. 2004;61:889-892.