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Treatment of Type 2 Diabetes: One Extreme to Another.


By Sarfraz Zaidi

Arch Intern Med. 2009;169(13):1246-1247.

Official Journal of the American Medical Association

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Glupride Multi




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Glupride Multi

Glupride Multi is a unique vitamin/herbal formula designed to promote healthy glucose levels naturally already within the normal range. 

Dr. Zaidi is a physician certified by the American Board of Internal Medicine. He is the medical director of the Jamila Diabetes & Endocrine Medical Center in Thousand Oaks, California. He frequently lectures other physicians and has written an instructional CD-ROM for physicians as well as several books.  

Vitamins and minerals are essential for the normal metabolism of our body. Endocrinologists are expert in the field of metabolism. They understand which vitamins and minerals are beneficial for the normal functioning of the body.  

Unfortunately, non-physicians have jumped into this field to take advantage of a good  business opportunity. Often, the public is misled by sale pitches, which have no scientific basis and sometimes may even be harmful. 

For example, most multivitamins contain Potassium. Most diabetic patients are on an Ace-inhibitor drug (such as Altace, Vasotec, Accupril, Zestril, etc.) or an ARB drug (such as Cozaar, Avapro, Atacand, Benicar, Diovan, etc.) These drugs can increase the potassium level in blood, which can be life-threatening. Potassium in a multi-vitamin can further increase this potassium level. Patients usually don't tell their physicians they're taking vitamins that contain potassium. When a physician encounters a patient with a high potassium level, they often stop the Ace-inhibitor or ARB drug, inadvertently depriving the patient of the beneficial effects of these helpful drugs. In contrast, all they had to do was to stop the multivitamin that contained potassium and advise the patient on a low potassium diet. 

Another problem: Most multivitamins contain vitamin K which may increase the amount of clotting factors in the body. Most diabetics have underlying insulin resistance, which increases the level of many clotting factors, which in turn increases risk for clot formation and acute vascular events, such as a heart attack and stroke.  An extra dose of Vitamin K in multivitamin preparations may actually be harmful in these patients. It's like adding fuel to the fire. Also, many of these patients are on Coumadin. Vitamin K interferes with Coumadin and it becomes extremely difficult to find the right dose of Coumadin in these patients.  

Many multivitamins also contain high dose of vitamin E. Most recent studies show that Vitamin E in large doses may not be cardio-protective and may even be harmful. However, most multi-vitamins continue to include mega doses of Vitamin E. 

Another problem: Most multivitamins also contain calcium and iron, both of which can interfere with the absorption of thyroid hormone, which many diabetic patients take.  


Ingredients in GLUPRIDE Multi  

Glupride-Multi does not contain Potassium, Vitamin K, Calcium or Iron. It contains small amounts of Vitamin E to meet the daily requirements.  

Glupride Multi contains 21 different vitamins, minerals and herbs. It contains Alpha-Lipoic Acid,  Chromium Picolinate, Cinnamon and Coenzyme Q 10 in addition to B vitamins, Vitamin A, Vitamin E, Vitamin C and essential minerals including Selenium, Zinc, Vanadium and Magnesium.


 Alpha-Lipoic Acid  

Alpha-lipoic acid is normally produced in cells in small amounts and helps in the normal metabolism of glucose. Alpha-lipoic acid functions as a strong anti-oxidant in the body (1, 2).*

The cells of diabetic patients are under a tremendous amount of daily oxidative stress. That's why it makes sense to use Alpha-Lipoic acid as a dietary supplement in people with diabetes.*  

A number of scientific studies have shown that alpha-lipoic acid promotes normal insulin sensitivity and thus may promote healthy glucose levels already in the normal range (2).*  

Several studies have also shown alpha-lipoic acid to be helpful in promoting nerve health in humans (3).* 

In Germany, Alpha-lipoic acid has been used for over 30 years. The amount of Alpha-lipoic acid is important! In these studies, the amount used was 600-1800 mg per day. Some multivitamins add a tiny amount of Alpha-lipoic acid, such as 100 mg per day. In contrast, we use a dose of 600 mg per day in Glupride Multi.


 Chromium picolinate  

Chromium picolinate is required for the normal metabolism of glucose.* Several studies have shown beneficial effects of chromium supplementation in promoting healthy glucose levels.*  

One large clinical trial tested chromium picolinate in 833 Type 2 diabetic patients and found a significant improvement in their blood glucose values (4).  

The amount of chromium picolinate is also important. Many multivitamins contain only a small amount of chromium picolinate. In contrast, we use a large dose of 600 mcg per day as was used in these clinical studies.* 



Physicians have long been intrigued by the beneficial effects of cinnamon on human health.

In December 2003,  an excellent scientific study was published in Diabetes Care, (5) in which cinnamon powder was used in 60 patients with Type 2 diabetes. Three daily doses, 1 gram, 3 grams and 6 grams were used. There was a decrease in blood glucose by 18-29%. Serum triglycerides also decreased by 23-30%. Patients consuming 6 grams of cinnamon powder per day appeared to have achieved results earlier (at 20 days), but at 40 days, all doses had the same efficacy in lowering blood glucose and triglycerides level.*


Coenzyme Q10

Coenzyme Q10 is a strong antioxidant.* It may help to improve diastolic dysfunction of the heart in patients with hypertension.

Statin drugs such as Lipitor (atorvastatin), Zocor (simvastatin), Pravachol (pravastatin), Mevacor (lovastatin) and Crestor (rosuvastatin) are commonly used in diabetic patients. Unfortunately, these drugs not only reduce cholesterol level, but also may reduce CoQ10  level in the muscles as was demonstrated in a recent study from investigators at Columbia University in the U.S. (6). This phenomenon may explain the muscle aches these patients often experience while on a statin drug. Co Q10 may help to prevent these muscle aches and pains.* 

Selenium, Zinc and Magnesium have all been shown to be beneficial to promote healthy glucos elevels already in the normal range.*  

Warnings – Disclaimer: This website is for educational purposes only. The information as well dietary supplements in this website are not intended to diagnose, treat, cure or prevent any disease. *These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are Not intended for use by pregnant or nursing women. If you are taking any medications, planning any medical or surgical procedure or have any medical condition, consult your doctor before using any of the supplements. Discontinue use and consult your doctor if any adverse reactions occur. Keep out of reach of children. Do not use if outer wrap is missing or torn. Store at room temperature.



Supplement Facts

Serving Size: 2 Tablets   

Servings per container: 30 Amount Per Serving 

Ingredient Amount % Daily Value
Vitamin A 5000 I.U. 100%
Vitamin C 100 mg   183% Vitamin E
Vitamin E 40 I.U. 132%
Thiamin   2 mg 133%
Riboflavin 2 mg 118%
Niacin 50 mg 250%
Vitamin B6 10mg     500%
Folic acid 800 mcg 200%
Vitamin B12 960mcg 16000%
Biotin 400 mcg 134%
Pantothenic acid 10 mg 100%
Magnesium Oxide 200 mg 50%
Iodine    450 mcg 300%
Zinc    20mg 133%
Selenium  100mcg 143%
Manganese  4 mg 200%
Chromium (as Chromium picolinate) 800mcg         667%
* Alpha Lipoic Acid 600 mg  
*Coenzyme Q 10  50 mg  
*Cinnamon bark powder 250 mg  
*Vanadium   10 mcg  

*Daily Value not established.


1.   Evans JL, Goldfine ID. Alpha-lipoic acid : a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Technol Ther 2000; 2: 401-413. 

 2.  Konrad T, Vicini P, Kusterer K et al. Alpha-Lipioc acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care 1999;22:280-287. 

 3.  Ziegler D, Reljanovic M, Mehnert H, Gries FA. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol Diabetes 1999;107:421-430.  

4.  Anderson R, Cheng N, bryden N, Polansky M, Cheng N, Chi J, Feng J. Elevated Intakes of supplemental chromium improves glucose and insulin variables in individuals with type 2 diabetes. Diabetes 1997;46:1786-1791.  

5.  Khan A, Safdar M, Khan M, Khan N, Anderson R. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;  

6.  Rundek T, Naini A, Sacco R, Coates K, DiMauro S. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol. 2004;61:889-892.   



Each bottle contains 60 tablets

        Regular Price = $54.95 per bottle

Sale Price = $ 44.95 per bottle          


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